Right click or control click on any PDF you have to 'Get info'. In the Get Info window, select Open With Preview & then select 'change all'. Now all your PDF will open with Preview. I've been getting along without Adobe Reader for years.
Message was edited by: Joe Gramm
If you want to trash Adobe Reader, drag the application to the trash, or right click on the application & select 'Move to Trash'. In your ~(Home Folder)/Library/Preferences, trash any folders or .plist files associated with Adobe Reader. Be careful to only trash Adobe Reader Files. Then in ~(Home Folder)/Library/Application Support, see if there are any folders or files associated with Adobe Reader. Again, be careful to only trash Adobe Reader files. & finally to be sure you got everything, you could do a Spotlight search for any else.